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0How does complement pathway overactivation cause damage to the kidney?
To learn more, choose the answer that you find the most likely:
- a Through cell injury caused by the membrane attack complex
- b Through the transmission of proinflammatory signals
- c Through the recruitment of leukocytes
- d All of the above
Show me the answer
The membrane attack complex (MAC) can induce cell activation and promote tissue injury, while complement cleavage products transmit proinflammatory signals, promote the release of cytokines and vasodilators, and recruit leukocytes.1 The kidney is particularly susceptible to complement-mediated damage due to structural features of the glomeruli.2
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